(4月18日15:00)报告1：主动脉瘤生长的修正弹性生长模型及监测应用，报告2：纳米颗粒弹性性能对细胞内吞的影响
报告题目1：主动脉瘤生长的修正弹性生长模型及监测应用
报告人: 吕朝锋 教授
浙江大学建筑工程学院
时间：2017年4月18日(周二) 15: 00
地点：中国科学院力学研究所1号楼344会议室
报告摘要：
主动脉瘤是心血管疾病的重要病症之一，传统基于超声成像、CT扫描、核磁共振等医学成像技术主要以尺寸为破裂风险评价指标，尚不能获得较好的破裂风险评估效果。报告介绍一种利用电活性高弹体电容式传感器实时监测主动脉瘤生长过程的新方法，并提出考虑生长残余应力影响的修正弹性生长模型以获得主动脉瘤的生长过程预测，建立传感器电容输出与主动脉瘤壁应力、壁厚、直径等多种生理参数的定量关系，为主动脉瘤生长提供实时监测和多参数破裂风险评估手段，提高主动脉瘤择时手术的决策效率。
报告人简介：
吕朝锋，现任浙江大学建筑工程学院教授、博士生导师。2001和2006年获浙江大学土木工程专业学士和博士学位，2006年7月留校任教。2007-2009年在香港城市大学建筑系做研究员，2010-2012年在美国西北大学土木与环境工程系做访问学者。主要研究方向为智能材料结构的多场耦合力学问题、软/硬材料组合结构的力学分析与设计、生物信息监测理论及其应用等。研究成果发表SCI收录论文70多篇，SCI他引2000余次，H指数23。申请和授权国家专利17项，获国家自然科学二等奖1项、教育部自然科学二等奖1项。国家优秀青年科学基金和浙江省杰出青年科学基金获得者，国家自然科学基金委创新研究群体骨干成员。担任国际期刊《Nano Communications》副主编，《Journal of Computational Engineering》编委，中国力学学会电子电磁器件工作组副组长。
报告题目2：纳米颗粒弹性性能对细胞内吞的影响
报告人: Xin Yi 助理教授
College of Engineering, Peking University
时间：2017年4月18日(周二) 16: 00
地点：中国科学院力学研究所1号楼344会议室
报告摘要：
Elastic particles including capsules, polymersomes and vesicular particles such as conventional liposomes are widely used in the fields of drug delivery. However, the mechanics of their interaction with cells are not very clear and there have been no systematic studies on the elasticity effects in cell uptake. In this talk, I will present our recent theoretical work on the interaction between elastic particles and cell membranes as well as vesicles. In particular, I will discuss how particle elasticity affect the membrane wrapping process, the kinetics of receptor-mediated endocytosis, and particle incorporation into a vesicle as well as outward budding from a vesicle. In the case of membrane wrapping, we found that soft nanoparticles are energetically less prone to full wrapping than stiff ones, but the wrapping of the former is kinetically faster than that of the latter. For the particle interaction with a vesicle, we found that soft particles are more energetically prone to full internalization into a vesicle than being released out of the vesicle.
报告人简介：
Xin Yi is an Assistant Professor in the College of Engineering, Peking University. He received his Ph.D. in Mechanical Engineering at Brown University in 2014. After that, he worked as a postdoctoral researcher at Brown University and Dartmouth College, before joining PKU in November 2016. He has selected in the 12th batch of the “Thousand Talents Program for Young Scholars” in 2016.
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